GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs6087771 | 1 | rs1484994 | chr20:30305975 | COX4I2 | chr20:30225691-30232800:+ | 0.22 | 4.59 | 6.11E-6 | Subcortical brain region volumes |
| BLCA | cis | rs1488193 | 1 | rs1488193 | chr3:112681585 | C3orf17 | chr3:112721294-112738555:- | -0.45 | -4.65 | 4.56E-6 | Economic and political preferences |
| BLCA | cis | rs10935120 | 1 | rs1498718 | chr3:134205920 | ANAPC13 | chr3:134196547-134204865:- | 0.47 | 7.39 | 9.45E-13 | Height |
| BLCA | cis | rs2243480 | 1 | rs1499613 | chr7:65730860 | CCT6P1 | chr7:65216092-65228661:+ | -0.35 | -4.72 | 3.27E-6 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs1499614 | chr7:65730798 | CCT6P1 | chr7:65216092-65228661:+ | 0.35 | 4.76 | 2.78E-6 | Diabetic kidney disease |
| BLCA | cis | rs523340 | 1 | rs1519466 | chr9:111860797 | C9orf5 | chr9:111777416-111882225:- | -0.29 | -3.93 | 0.0001 | Information processing speed |
| BLCA | cis | rs30187 | 1 | rs151964 | chr5:96123666 | ERAP1 | chr5:96096515-96149837:- | -0.51 | -10.92 | 2.47E-24 | Ankylosing spondylitis |
| BLCA | cis | rs30187 | 1 | rs151964 | chr5:96123666 | ERAP2 | chr5:96211644-96255398:+ | 0.32 | 5.44 | 9.74E-8 | Ankylosing spondylitis |
| BLCA | cis | rs9783347 | 1 | rs1520884 | chr11:18309700 | GTF2H1 | chr11:18343816-18388590:+ | -0.29 | -5.43 | 9.82E-8 | Pancreatic cancer |
| BLCA | cis | rs11976180 | 1 | rs1533266 | chr7:143766714 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -6.02 | 3.98E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs1533267 | chr7:143766440 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -6.08 | 2.92E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs1533268 | chr7:143766358 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -6.06 | 3.3E-9 | Obesity-related traits |
| BLCA | cis | rs10935120 | 1 | rs1534025 | chr3:134313304 | ANAPC13 | chr3:134196547-134204865:- | -0.5 | -7.84 | 4.46E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs1534025 | chr3:134313304 | CEP63 | chr3:134204575-134293852:+ | -0.24 | -4.1 | 5.07E-5 | Height |
| BLCA | cis | rs10935120 | 1 | rs1534026 | chr3:134284767 | ANAPC13 | chr3:134196547-134204865:- | 0.49 | 7.74 | 8.99E-14 | Height |